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Objective To examine the safety of using aliskiren combined with agents used to block the renin-angiotensin system.
For the purpose of the analyses we considered ACE inhibitors and angiotensin receptor blockers together as one class.
We excluded drug combinations with agents other than ACE inhibitors and angiotensin receptor blockers—for example, combined telmisartan and hydrochlorothiazide.
No language restrictions were applied and we reviewed the bibliographies of identified articles to locate further eligible studies.
In addition we searched the Clinical trials registry ( the Novartis clinical trial results database, and abstracts of the past five years from conferences of the American Society of Nephrology and the European Renal Association for ongoing or completed trials.
Results 10 randomised controlled studies (4814 participants) were included in the analysis.
Our tube site is one of better places to enjoy Arab porn vids. We carried out a systematic review and meta-analyses of the safety of using aliskiren combined with an ACE inhibitor or angiotensin receptor blocker.We used a strategy developed with a health informatics specialist (see web extra on bmj.com) to search Ovid Medline (1948 to ), Embase (1980 to ), and the Cochrane central register of controlled trials (1993 to ).Two authors (ZH and CG) scanned titles and abstracts for initial selection.Selected articles were reviewed in full and independently assessed for eligibility by the same two reviewers. The primary outcome was hyperkalaemia, defined as a serum potassium concentration greater than 5.5 mmol/L (meq/L).